INSERM U963 / CNRS UPR9022Navigation
From basic research to intervention strategies against parasites
Les Embiez Island, France
Tools for Anopheles gambiae Transgenesis. Volohonsky G.*, Terenzi O.*, Soichot J.*, Naujoks D.A., Nolan T., Windbichler N., Kapps D., Smidler A.L., Vittu A., Costa G., Steinert S., Levashina E.A., Blandin S.A. and Marois E., 2015 – Genes, Genomes, Genetics 13;5(6):1151-63 pubmedRead More
A brand new, larger and more functional insectarium will be constructed starting in 2015. The project is funded by the government-impulsed “Plan Campus“, of which the University of Strasbourg is a laureate. The new building will triple the space currently dedicated to mosquito breeding and highly-secured laboratories, in which experiments involving the human malaria parasite Plasmodium falciparum and mosquito-borne viral pathogens will be possible. By extending our current research on the mouse malaria model to the human malaria parasite, and to the transmission of viral pathogens by mosquitoes, the new insectary will allow us and our colleagues working on Drosophila to answer questions directly relevant to human...Read More
INSERM U963 / CNRS UPR9022 - Strasbourg, France
About 20 species of mosquitoes in the genus Anopheles are known vectors of Plasmodium, transmitting the parasite while taking a blood meal on humans. Among them, Anopheles gambiae is the major malaria vector in sub-Saharan Africa. Importantly, mosquitoes are not mere needles that transmit the parasites, they actively fight the parasite. In some mosquitoes, parasite development is even completely blocked early after infection, making these mosquitoes unable to transmit the disease. We aim at understanding the genetic basis of the resistance/susceptibility of mosquitoes towards Plasmodium, and we develop new tools for efficient mosquito transgenesis to investigate mosquito-parasite interactions.Left photos : GFP-expressing parasites are visible on the midgut of a mosquito from the susceptible strain while mosquitoes from the resistant strain are devoid of live parasites. Right photo : transgenic larvae of a strain we call “french kiss”.