INSERM U963 / CNRS UPR9022Navigation
Malaria today is the second-most important human disease after AIDS, killing over 600,000 people annually, the majority of whom are infants in sub-Saharan Africa. More than 200 million people are infected every year in 108 countries, and half of the human population is at risk...Read More
A brand new, larger and more functional insectarium will be constructed starting in 2015. The project is funded by the government-impulsed “Plan Campus“, of which the University of Strasbourg is a laureate. The new building will triple the space currently dedicated...Read More
INSERM U963 / CNRS UPR9022 - Strasbourg, France
About 20 species of mosquitoes in the genus Anopheles are known vectors of Plasmodium, transmitting the parasite while taking a blood meal on humans. Among them, Anopheles gambiae is the major malaria vector in sub-Saharan Africa. Importantly, mosquitoes are not mere needles that transmit the parasites, they actively fight the parasite. In some mosquitoes, parasite development is even completely blocked early after infection, making these mosquitoes unable to transmit the disease. We aim at understanding the genetic basis of the resistance/susceptibility of mosquitoes towards Plasmodium, and we develop new tools for efficient mosquito transgenesis to investigate mosquito-parasite interactions.Left photos : GFP-expressing parasites are visible on the midgut of a mosquito from the susceptible strain while mosquitoes from the resistant strain are devoid of live parasites. Right photo : transgenic larvae of a strain we call “french kiss”.