Chandra Ramakrishnan

Chandra Ramakrishnan 

Post-doctoral Researcher

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BIOGRAPHY


Chandra Ramakrishnan obtained her degree in Chemistry and Molecular Biology at the Swiss Federal Institute of Technology Zurich (ETHZ) in 2002 where she studied the secreted chorismate mutase from Mycobacterium tuberculosisunder the supervision of Dr. Peter Kast. In 2003, she then started her PhD at Imperial College London in the group of Prof. Robert E. Sinden. Her research was focused on the characterisation of the essential ookinete protein CTRP in Plasmodium berghei and was funded by the Boehringer Ingelheim Foundation. At Imperial College, Chandra also started working on culturing sexual stages of Plasmodium falciparum. In 2008, she moved to the Institut de Biologie Moléculaire et Cellulaire (IBMC) in the UPR9022 of the CNRS in Strasbourg, France to do postdoctoral research in the area of mosquito immunity under the supervision of Dr. Elena A. Levashina and Dr. Stéphanie A. Blandin. In 2010, Chandra returned to Prof. Sinden’s lab to study transmission-blocking vaccines.

PUBLICATIONS


12. An Ancient Protein Phosphatase, SHLP1, Is Critical to Microneme Development in Plasmodium Ookinetes and Parasite Transmission. Patzewitz EM, Guttery DS, Poulin B, Ramakrishnan C, Ferguson DJ, Wall RJ, Brady D, Holder AA, Szöőr B, Tewari R., 2013 – Cell Rep. pii: S2211-1247(13)00056-9. doi: 10.1016/j.celrep.2013.01.032. pubmed

11. Measuring the blockade of malaria transmission – an analysis of the standard membrane feeding assay. Churcher TS, Blagborough AM, Delves M, Ramakrishnan C, Kapulu MC, Williams AR, Biswas S, Da DF, Cohuet A, Sinden RE, 2012 – Int J Parasitol (in press) pubmed

10. A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines. Delves MJ, Ramakrishnan C, Blagborough AM, Leroy D, Wells TNC, Sinden RE, 2012 – Int J Parasitol (in press) pubmed

9. A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion. Guttery DS, Poulin B, Ferguson DJP, Szoor B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM, Straschil U, Solyakov L, Green JL, Sinden RE, Tobin AB, Holder AA, Tewari R, 2012 – PLoS Pathogens (in press) pubmed

8. Laboratory maintenance of rodent malaria parasites. Ramakrishnan C, Delves MJ, Lal K, Blagborough AM, Butcher G, Baker KW, Sinden RE., 2013 – Methods Mol Biol. 923:51-72. pubmed

7. Assessing Transmission Blockade in Plasmodium spp. Blagborough AM, Delves MJ, Ramakrishnan C, Lal K, Butcher G, Sinden RE, 2013 – Methods Mol Biol. 923:577-600 pubmed

6. The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium. Sinden R.E., Blagborough A. M., Churcher T., Ramakrishnan C., Biswas S., Delves M.J., 2012 – Trends in Parasitology pii: S1471-4922(12)00123-7. doi: 10.1016/j.pt.2012.07.005 pubmed

5. Salivary gland-specific P. berghei reporter lines enable rapid evaluation of tissue-specific sporozoite loads in mosquitoes. Ramakrishnan C*, Rademacher A*, Soichot J, Costa G, Waters AP, Janse CJ, Ramesar J, Franke-Fayard BM, Levashina EA. (*equal contribution), 2012 – PLoS One. 2012;7(5):e36376 pubmed

4. Vital functions of the malarial ookinete protein, CTRP, reside in the A domains. Ramakrishnan C., Dessens J. T., Armson R., Pinto S. B., Talman A. M., Blagborough A. M., Sinden R. E., 2011 – Int J Parasitol. 41(10):1029-39. pubmed

3. Discovery of Plasmodium modulators by genome-wide analysis of circulating hemocytes in Anopheles gambiae. Pinto S.B., Lombardo F., Koutsos A.C., Waterhouse R.M., McKay K., An C., Ramakrishnan C., Kafatos F.C., Michel K., 2009 – Proc Natl Acad Sci U S A. 106(50):21270-5 pubmed 

2. Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved. Krengel U., Dey R., Sasso S., Okvist M., Ramakrishnan C., Kast P., 2006 – Acta Crystallograph Sect F Struct Biol Cryst Commun. 62 :441-445 pubmed

1. Characterization of the secreted chorismate mutase from the pathogen Mycobacterium tuberculosis. Sasso S., Ramakrishnan C., Gamper M., Hilvert, D., Kast P., 2005 – FEBS J. 272, 375-389 pubmed