Christine Kappler


KAPPLER_Christine-2Christine Kappler  

Engineer of CNRS

tel: (+33) 3 88 41 70 96
fax: (+33) 3 88 60 69 22

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BIOGRAPHY


1988 : PhD in Biochemistry – Topic : “Ecdysone Biosynthesis” – University of Strasbourg

in the lab since 2002

PUBLICATIONS


27. High-throughput sorting of mosquito larvae for laboratory studies and for future vector control interventions. Marois E, Scali C, Soichot J, Kappler C, Levashina EA, Catteruccia F., 2012 – Malar J. 11(1):302 pubmed

26. Cg-Rel, the first Rel/NF-kappaB homolog characterized in a mollusk, the Pacific oyster Crassostrea gigas. Montagnani C., Kappler C., Reichhart J.M., Escoubas J.M. 2004 FEBS Lett. 561(1-3):75-82 pubmed

25. The Drosophila Immune Defense against Gram-negative infection requires the death protein dFADD. Naitza S., Rossé C., Kappler C., Georgel P., Belvin M., Gubb D., Camonis J., Hoffmann J.A. and Reichhart J.M. 2002 Immunity 17(5):575-581 pubmed

24. Drosophila Immune Deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Georgel P., Naitza S., Kappler C., Ferrandon D., Zachary D., Swimmer C., Kopczynski C., Duyk G., Reichhart J-M. and Hoffmann J.A. 2001 Developmental Cell 1(4):503-514 pubmed

23. Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Gross I., Georgel P., Kappler C., Reichhart J.M. & Hoffmann J.A. 1996 Nucleic Acids Res. 24:1238-45 pubmed

22. Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter. Georgel P., Kappler C., Langley E., Gross I., Nicolas E., Reichhart J.M. & Hoffmann J.A. 1995 Nucleic Acids Res. 23:1140-5 pubmed

21. Immune gene expression in Drosophila. In Phylogenetic Perspectives in Immunity: the Insect host defense. Meister M., Georgel P., Lemaitre B., Kappler C., Lagueux M., Reichhart J.M. & Hoffmann J. A. 1994 Edited by J. A. Hoffmann, C. A. Janaway & S. Natori

20. Insect immunity. A transgenis analysis in Drosophila defines several functional domains in the diptericin promoter. Meister M., Braun A., Kappler C., Reichhart J.M. and Hoffmann J.A. 1994 EMBO J. 13(24):5958-5966 pubmed

19. Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila. Reichhart J.M., Georgel P., Meister M., Lemaitre B., Kappler C. & Hoffmann J.A. 1993. C R Acad. Sci. III 316:1218-24 pubmed

18. Insect Immunity. Two 17 bp repeats nesting a kB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria challenged Drosophila. Kappler C., Meister M., Lagueux M., Gateff E., Hoffmann J.A. and Reichhart J.M. 1993 EMBO J. 12(4):1561-1568 pubmed

17. Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements. Georgel P., Meister M., Kappler C., Lemaitre B., Reichhart J. M. & Hoffmann J. A. 1993 Biochem. Biophys. Res. Commun. 197:508-17 pubmed

16. Synthesis of high specific activity (3H2-1,2)-7-dehydrocholesterol. Conversion to ecdysone in follicle cells of Locusta (Insects)). Dolle F., Kappler C., Hetru C., Rousseau B., Coppo M., Luu B. & Hoffmann J. A. 1990 Tetrahedron 46:5305-5316

15. Characterization of three hydroxylases involded in the final steps of biosynthesis of the steroid hormone ecdysone in Locusta migratoria (Insecta, Orthoptera). Kappler C., Kabbouh M., Hetru C., Durst F. and Hoffmann J.A. 1988 J. steroid Biochem. 31(6):891-898 pubmed

14. Study on the biosynthesis of ecdysone. Part IV: Synthesis of high specific activity (3H2-22,23)-2,22- dideoxyecdysone. Tissue distribution of the C-22 hydroxylase in Locusta migratoria. Haag T., Hetru C., Kappler C., Moustier A.M., Hoffmann J. A. & Luu B. 1988 Tetrahedron 44:1397-1408

13. Further characterization of the 2-deoxyecdysone C-2 hydroxylase from Locusta migratoria. Kabbouh M., Kappler C., Hetru C. & Durst F. 1987 Insect Biochem. 17:1155-1164

12. (3H4)Beta-hydroxy-5Beta-cholest-7en-6one: critical re-evaluation of its role in Locusta migratoria. Haag T., Meister M., Hetru C., Kappler C., Nakatani Y., Beaucourt J. P., Rousseau B. & Luu B. 1987 Insect Biochem. 17:291-301

11. In vitro studies on potential selective and irreversible inhibitors of enzymes involved in the biosynthesis of edcysone. Burger A., Roussel J. P., Colobert F., Kappler C., Hetru C., Luu B. & Hoffmann J. A. 1987 Pesticide Biochemisty and Physiology 29

10. Studies on the C-2 hydroxylasetion of 2-deoxyecdysone in Locusta migratoria. Kappler C., Kabbouh M., Durst F. & Hetru C. 1986 Insect Biochem. 16:25-32

9. Role of the follicle cells and the oocytes in ecdysone biosynthesis and esterification in vitollegenic females of Locusta migratoria. Kappler C., Goltzene F., Lagueux M., Hetru C. & Hoffmann J. A. 1986 Intern. J. of Invertebrate Reproduction and Development. 9:17-34

8. Role of ecdysone in reproduction of Insects: A critical analysis. In Advances in Invertebrate Reproduction 4. Hoffmann J. A., Lagueux M., Hetru C., Kappler C., Goltzene F., Lanot R. & Thiebold J. 1986 Edited by M. Porchet, J. C. Andries & A. Dhainaut: Elsevier Science Publishers

7. Conversion of a radiolabelled ecdysone precursor, 2,22,25-trideoxyecdysone, by embryonic and larval tissues of Locusta migratoria. Meister M. F., Dimarcq J. L., Kappler C., Hetru C., Lagueux M., Lanot R., Luu B. & Hoffmann J. A. 1985 Mol. Cell Endocrinol. 41:27-44 pubmed

6. Recherches sur la conversion in vitro d’un précurseur de biosynthèse d’ecdysone, la 2,22,25- trideoxyecdysone, par des tissus embryonnaires et larvaires de Locusta migratoria (Insecte Orthoptère). Meister M., Dimarcq J. L., Kappler C., Hetru C., Bang L. & Hoffmann J. A. 1985 C. R. Acad. Sc. Paris 300, Série III, 347-352

5. Ecdysteroids in ovaries and embryos of Locusta migratoria. Lagueux M., Hoffmann J. A., Goltzene F.,Kappler C., Tsoupras G., Hetru C. & Bang L. 1984 In Biosynthesis, metabolism and mode of action of invertebrate hormones, pp. 168-180. Edited by J. A. Hoffmann & M. Porchet. Berlin, Heidelberg: Springer-Verlag

4. Fate of maternal conjugated ecdysteroids during embryonic development in Locusta migratoria. Sall C., Tsoupras G., Kappler C., Lagueux M., Zachary D., Luu B. & Hoffmann J. A. 1983 J. Insect Physiol. 29:491-507

3. The biosynthetic pathway of ecdysone: studies with vitellogenic ovaries of Locusta migratoria (Orthoptera). Hetru C., Kappler C., Hoffmann J. A., Nearn R., Bang L. & Horn D. H. 1982 Mol. Cell Endocrinol. 26:51-80 pubmed

2. Ecdysteroids and ovarian development in the shore crab, Carcinus maenas. Lachaise F., Goudeau M., Hetru C., Kappler C. & Hoffmann J. A. 1981 Hoppe Seylers Z Physiol. Chem. 362:521-9 pubmed

1. Ecdysone titre and metabolism in relation to cuticulogenesis in embryos of Locusta migratoria. Lagueux M., Hetru C., Goltzene F., Kappler C. & Hoffmann J. A. 1979 J. Insect Physiol. 25:703-723