Elena A. Levashina

Elena A. LevashinaFRRU


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1994 : Ph.D. in Genetics – Cell selection in vitro for the development of plant stocks resistant to the phytosterol-dependent insects – Department of Genetics and Breeding – St-Petersbourg State University (Russia) Supervisor : Prof. L.A.Lutova


53. A New Role of the Mosquito Complement-like Cascade in Male Fertility in Anopheles gambiaePompon J., Levashina E.A., 2015 – PLoS Biol. 13(9):e1002255. pubmed

52. Tools for Anopheles gambiae Transgenesis. Volohonsky G.*, Terenzi O.*, Soichot J.*, Naujoks D.A., Nolan T., Windbichler N., Kapps D., Smidler A.L., Vittu A., Costa G., Steinert S., Levashina E.A., Blandin S.A. and Marois E., 2015 – Genes, Genomes, Genetics 5(6):1151-63 pubmed

50. Evidence of natural Wolbachia infections in field populations of Anopheles gambiaeBaldini F.*, Segata N.*, Pompon J.*, Marcenac P., Shaw W.R., Dabire R.K., Diabate A., Levashina E.A. & Catteruccia F., 2014 – Nature Communications in press

49. Targeted Mutagenesis in the Malaria Mosquito Using TALE Nucleases. Smidler A. L., Terenzi O., Soichot J., Levashina E. A., Marois E., 2013 PLoS One 8(8):e74511 pubmed

48. AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiaeNsango SE, Pompon J, Xie T, Rademacher A, Fraiture M, Thoma M, Awono-Ambene PH, Moyou RS, Morlais I, Levashina EA., 2013 – J Biol Chem. [Epub ahead of print] pubmed

47. Silencing of Genes and Alleles by RNAi in Anopheles gambiae. Lamacchia M, Clayton JR, Wang-Sattler R, Steinmetz LM, Levashina EA, Blandin SA., 2012 – Methods Mol Biol. 923:161-76 pubmed

46. High-throughput sorting of mosquito larvae for laboratory studies and for future vector control interventions. Marois E, Scali C, Soichot J, Kappler C, Levashina EA, Catteruccia F., 2012 – Malar J. 11(1):302 pubmed

45. Lawrence’s book review unfair to Hoffmann. Ezekowitz A, Dimarcq JL, Kafatos F, Levashina E, Ferrandon D, Hetru C, Imler JL, Reichhart JM., 2012 – Curr Biol. 2012 Jun 19;22(12):R482

44. Midgut microbiota of the malaria mosquito vector Anopheles gambiae and interactions with Plasmodium falciparum infection. Boissière A, Tchioffo MT, Bachar D, Abate L, Marie A, Nsango SE, Shahbazkia HR, Awono-Ambene PH, Levashina EA, Christen R, Morlais I., 2012 – PLoS Pathog. 8(5):e1002742. pubmed

43. Salivary gland-specific P. berghei reporter lines enable rapid evaluation of tissue-specific sporozoite loads in mosquitoes. Ramakrishnan C, Rademacher A, Soichot J, Costa G, Waters AP, Janse CJ, Ramesar J, Franke-Fayard BM, Levashina EA., 2012 – PLoS One. 7(5):e36376 pubmed

42. Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiaeNsango SE, Abate L, Thoma M, Pompon J, Fraiture M, Rademacher A, Berry A, Awono-Ambene PH, Levashina EA, Morlais I., 2012 – Int J Parasitol. 42(6):589-95. pubmed

41. Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system. Buresova V, Hajdusek O, Franta Z, Loosova G, Grunclova L, Levashina EA, Kopacek P., 2011 – J Innate Immun. 3(6):623-30. pubmed

40. Intracellular immune responses of dipteran insects. Steinert S, Levashina EA., 2011 – Immunol Rev. 240(1) : 129-40 pubmed

39. A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Baxter R.H., Steinert S., Chelliah Y., Volohonsky G., Levashina E.A., Deisenhofer J., 2010 – Proc. Natl. Acad. Sci. U S A. 107(39):16817-22 pubmed

38. The Major Yolk Protein Vitellogenin Interferes with the Anti-Plasmodium Response in the Malaria Mosquito Anopheles gambiae. Rono M.K., Whitten M.M., Oulad-Abdelghani M., Levashina E.A., Marois E., 2010 – PLoS Biol. 8(7):e1000434 pubmed

37. Focusing on complement in the antiparasitic defense of mosquitoes. Volohonsky G, Steinert S, Levashina EA., 2010 – Trends Parasitol. 26(1):1-3 pubmed

36. Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Blandin SA, Wang-Sattler R, Lamacchia M, Gagneur J, Lycett G, Ning Y, Levashina EA, Steinmetz LM., 2009 – Science 326(5949):147-50 pubmed

35. RNAi in the malaria vector, Anopheles gambiae. Catteruccia F, Levashina EA, 2009 – Methods Mol Biol. 555:63-75 pubmed

34. Two Mosquito LRR Proteins Function as Complement Control Factors in the TEP1-Mediated Killing of Plasmodium. Fraiture M, Baxter RH, Steinert S, Chelliah Y, Frolet C, Quispe-Tintaya W, Hoffmann JA, Blandin SA, Levashina EA., 2009 – Cell Host Microbe. 19;5(3):273-84 pubmed

33. Molecular and cellular components of the mating machinery in Anopheles gambiae females. Rogers DW, Whitten MM, Thailayil J, Soichot J, Levashina EA, Catteruccia F., 2008 – Proc Natl Acad Sci U S A. 9;105(49):19390-5. pubmed

32. Host-parasite interactions: the balance of trade. Levashina EA., 2008 Curr Opin Microbiol. 11(4):338-9. pubmed

31. Antimalarial responses in Anopheles gambiae: from a complement-like protein to a complement-like pathway. Blandin SA, Marois E, Levashina EA., 2008 – Cell Host Microbe. 12;3(6):364-74. Review. pubmed

30. Reverse Genetics Analysis of Antiparasitic Responses in the Malaria Vector, Anopheles gambiae. Blandin S.A., Levashina E.A., 2008 – Methods Mol Biol. 415:365-77 pubmed

29. Phagocytosis in mosquito immune responses. Blandin S.A., Levashina E.A. 2007 – Immunol Rev. 219:8-16. pubmed

28. Structural basis for conserved complement factor-like function in the antimalarial protein TEP1. Baxter R.H., Chang C.I., Chelliah Y., Blandin S., Levashina E.A., Deisenhofer J. 2007 – Proc. Natl. Acad. Sci. U.S.A. 104(28):11615-20 pubmed

27. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Waterhouse R.M., Kriventseva E.V., Meister S., Xi Z., Alvarez K.S., Bartholomay L.C., Barillas-Mury C., Bian G., Blandin S., Christensen B.M., Dong Y., Jiang H., Kanost M.R., Koutsos A.C., Levashina E.A., Li J., Ligoxygakis P., Maccallum R.M., Mayhew G.F., Mendes A., Michel K., Osta M.A., Paskewitz S., Shin S.W., Vlachou D., Wang L., Wei W., Zheng L., Zou Z., Severson D.W., Raikhel A.S., Kafatos F.C., Dimopoulos G., Zdobnov E.M., Christophides G.K. 2007 – Science 316(5832):1738-43. pubmed

26. Malaria Plasmodium agent induces alteration in the head proteome of their Anopheles mosquito host. Lefevre T., Thomas F., Schwartz A., Levashina E.A., Blandin S., Brizard J-P., Le Bourligu L., Demettre E., Renaud F., Biron D.G., 2007 – Proteomics 7(11):1908-15. pubmed

25. Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut. Shiao S.H., Whitten M.M., Zachary D., Hoffmann J.A., Levashina E.A., 2006 – PLoS Pathog. 2(12):e133. pubmed

24. Boosting NF-kB Dependent Basal Immnity of Anopheles gambiae Aborts Development of Plasmodium berghei. Frolet C., Thoma M., Blandin S., Hoffmann J.A. and Levashina E.A. 2006 – Immunity 25(4):677-85. pubmed

23. Cell biology, compartmentalization and immunology of mosquito midgut – malaria parasite interactions. Whitten M.M.A., Shiao S.-H., Levashina E.A. 2006 – Parasite Immunology 28(4):121-130 (Review). pubmed

22. In Vivo Identification of Novel Regulators and Conserved Pathways of Phagocytosis in A. gambiae. Moita L.F., Wang R., Michel K., Blandin S., Zimmermann T., Levashina E.A. and Kafatos F.C., 2005 – Immunity 23(1):65-73. pubmed

21. Curing mosquitoes to control malaria ? Blandin S. and Levashina, E. A., 2004 – Med. Sci. (Paris) 20(8-9):740-742. pubmed

20. Immune responses and parasite transmission in blood-feeding insects. Lehane M.J., Aksoy S., and Levashina E.A., 2004 – Trends in Parasitology 20(9):433-439 (Review). pubmed

19. Immune responses in Anopheles gambiae. Levashina E.A., 2004 – Insect Biochem. Mol. Biol. 34(7):673-678 (Review). pubmed

18. Bacterial alpha2-macroglobulins: colonization factors acquired by horizontal gene transfer from the metazoan genome ? Budd A., Blandin S., Levashina E.A., and Gibson TJ., 2004 – Genome Biology 5(6):R38. pubmed

17. Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae. Blandin S, Shiao S.-H, Moita L.F., Janse C.J., Waters A.P., Kafatos F.C., Levashina E.A., 2004 – Cell 116(5):661-670. pubmed

16. Thioester-containing proteins in insect immunity. Blandin S. and Levashina E.A., 2004 – Mol. Immunol. 40(12):903-908 (Review). pubmed

15. Mosquito immune responses against malaria parasites. Blandin S. and Levashina E.A., 2004 – Curr. Opin. Immunol. 16(1):16-20 (Review). pubmed

14. Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies. Goto A., Blandin S., Royet J., Reichhart J-M., Levashina E.A., 2003 – Nucleic Acids Res. 31(22):6619-6623 pubmed

13. Immunity-related genes and gene families in Anopheles gambiae. Christophides G.K., Zdobnov E., Barillas-Mury C., Birney E., Blandin S., Blass C., Brey P.T., Collins F.H., Danielli A., Dimopoulos G., Hetru C., Hoa N.T., Hoffmann J.A., Kanzok S.M., Letunic I., Levashina E.A., Loukeris T.G., Lycett G., Meister S., Michel K., Moita L.F., Muller H.M., Osta M.A., Paskewitz S.M., Reichhart J.-M., Rzhetsky A., Troxler L., Vernick K.D., Vlachou D., Volz J., von Merig C., Xu J., Zheng L., Bork P., Kafatos F.C. 2002 – Science 298(5591):159-165 pubmed

12. Reverse genetics in the mosquito, Anopheles gambiae: targeted disruption of the Defensin gene. Blandin S., Moita L.F, Kocher T., Wilm M., Kafatos F.C., Levashina E.A., 2002 – EMBO Reports 3(9):852-856 pubmed

11. Thioester-Containing Proteins of Protostomes. Levashina E.A., Blandin S., Moita L.F., Lagueux, M., Kafatos F.C., 2002 – In Infectious Disease: Innate Immunity. Ezekowitz R.A.B. and Hoffmann J.A., eds. Humana Press Inc, Totowa, NJ, 155-173.

10. Conserved Role of a Complement-like Protein in Phagocytosis Revealed by dsRNA Knockout in Cultured Cells of the Mosquito, Anopheles gambiae. Levashina E.A., Moita L.F., Blandin S., Vriend G., Lagueux M., Kafatos F.C., 2001 – Cell 104(5):709-718 pubmed

9. Innate immune defense against malaria infection in the mosquito. Dimopoulos G., Muller H.-M., Levashina E.A., Kafatos F.C., 2001 – Curr. Opin. Immunol. 13(1):79-88 (Review) pubmed

8. The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2. Green C., Levashina E.A., McKimmie C., Dafforn T., Reichhart J.-M., and Gubb D., 2000 – Genetics 156(3):1117-1127 pubmed

7. Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants of Drosophila. Lagueux M., Perrodou E., Levashina E.A., Capovilla M., and Hoffmann J.A., 2000 – Proc. Natl. Acad. Sci. U.S.A. 97(21):11427-11432 pubmed

6. Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila. Levashina E.A., Langley E., Green C., Gubb D., Ashburner M., Hoffmann J.A., and Reichhart J.-M., 1999 – Science 285(5435):1917-1919 pubmed

5. Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin. Levashina E.A., Ohresser S., Lemaitre B. and Imler J.-L., 1998 – J. Mol. Biol. 278(3):515-527 pubmed

4. Similarities between insect and plant host defenses. Levashina E.A., 1997 – Trends Cell Biol. 7(8):316 (Review) pubmed

3. Metchnikowin, a Novel 3 kDa Inducible Antimicrobial Peptide of Drosophila: Characterization, cDNA cloning and Expression Studies. Levashina E.A., Ohresser S., Bulet P., Reichhart J-M., Hetru C., and Hoffmann J.A., 1995 – Eur. J. Biochem. 233(2):694-700 pubmed

2. The Influence of Plant Phenotype on the Processes of Regeneration. Lutova L.A., Bondarenko L.V., Buzovkina I.S., Levashina E.A., Tikhodeev O.N., Khodzhaiova L.T., Sharova N.V., and Shishkova S.O., 1994 – Russian Journal of Genetics 30:1065-1074 (in Russian)

1. Sterol Biosynthesis Mutants of Higher Plants. Lutova L.A., Levashina E.A., Bondarenko L.V., Bayramova N.L., Andronova E.V., Inge-Vechtomov S.G., 1992 – Genetika 28:129-136 (in Russian)