Stéphanie Blandin

 

Stéphanie Blandin

Group Leader – CR1 of INSERM

tel: (+33) 3 88 41 – 70 76 / – 70 95
fax: (+33) 3 88 60 69 22

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BIOGRAPHY


Joint PhD 2004, EMBL Heidelberg and University of Strasbourg
Postdoctoral research at EMBL and IBMC in Strasbourg
Inserm Staff researcher at IBMC since 2007
Head of Inserm U963 since 2012
In the Lab since 2005

PUBLICATIONS


28. Arylmethylamino steroids as antiparasitic agents. K Krieg, E Jortzik, Alice-Anne Goetz, Stéphanie Blandin, S Wittlin, M Elhabiri, M Rahbari, S Nuryyeva, K Voigt, H-M Dahse, A Brakhage, S Beckmann, T Quack, CG Grevelding, AB Pinkerton, B Schönecker, J Burrows, E Davioud-Charvet, S Rahlfs, K Becker, 2017 – Nat Commun 8:14478 pubmed

27. Transgenic expression of the anti-parasitic factor TEP1 in the malaria mosquito Anopheles gambiae.  G Volohonsky, A-K Hopp, Mélanie Saenger, Julien Soichot, H Scholze, J Boch, Stéphanie Blandin, Eric Marois, 2017  – PLoS Pathog  13(1):e1006113 pubmed

26. The redox-cycler plasmodione is a fast acting antimalarial lead compound with pronounced activity against sexual and early asexual blood-stage parasites, K Ehrhardt, C Deregnaucourt, Alice-Anne Goetz, T Tzanova, V Gallo, P Arese, B Pradines, SH Adjalley, D Bagrel, Stéphanie Blandin, M Lanzer, E Davioud-Charvet, 2016 – Antimicrob Agents Chemother 60:5146-5158 pubmed

25. Tools for Anopheles gambiae Transgenesis. G Volohonsky, Olivier Terenzi, Julien Soichot, D-A Naujoks, T Nolan, N Windbichler, D Kapps, AL Smidler, A Vittu, G Costa, S Steinert, EA Levashina, Stépahnie Blandin, Eric Marois, 2015 – Genes, Genomes, Genetics 5(6):1151-63 pubmed

24. Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes. Neafsey D.E., Waterhouse R.M., Abai M.R., Aganezov S.S., Alekseyev M.A., Allen J.E., Amon J., Arcà B., Arensburger P., Artemov G., Assour L.A., Basseri H., Berlin A., Birren B.W., Blandin S.A., Brockman A.I., Burkot T.R., Burt A., Chan C.S., Chauve C., Chiu J.C., Christensen M., Costantini C., Davidson V.L.M., Deligianni E., Dottorini T., Dritsou V., Gabriel S.B., Guelbeogo W.M., Hall A.B., Han M.V., Hlaing T., Hughes D.S.T., Jenkins A.M., Jiang X., Jungreis I., Kakani E.G., Kamali M., Kemppainen P., Kennedy R.C., Kirmitzoglou I.K., Koekemoer L.L., Laban N., Langridge N., Lawniczak M.K.N., Lirakis M., Lobo N.F., Lowy E., MacCallum R.M., Mao C., Maslen G., Mbogo C., McCarthy J., Michel K., Mitchell S.N., Moore W., Murphy K.A., Naumenko A.N., Nolan T., Novoa E.M., O’Loughlin S., Oringanje C., Oshaghi M.A., Pakpour N., Papathanos P.A., Peery A.N., Povelones M., Prakash A., Price D.A., Rajaraman A., Reimer L.J., Rinker D.C., Rokas A., Russell T.L., Sagnon N’F., Sharakhova M.V., Shea T., Simão F.A., Simard F., Slotman M.A., Somboon P., Stegniy V., Struchiner C.J., Thomas G.W.C., Tojo M., Topalis P., Tubio J.M.C., Unger M.F., Vontas J., Walton C., Wilding C.S., Willis J.H., Wu Y-C., Yan G., Zdobnov E.M., Zhou X., Catteruccia F., Christophides G.K., Collins F.H., Cornman R.S., Crisanti A., Donnelly M.J., Emrich S.J., Fontaine M.C., Gelbart W., Hahn M.W., Hansen I.A., Howell P.I., Kafatos F.C., Kellis M., Lawson D., Louis C., Luckhart S., Muskavitch M.A.T., Ribeiro J.M., Riehle M.A., Sharakhov I.V., Tu Z., Zwiebel L.J., and Besansky N.J., 2014 – Science  [DOI:10.1126/science.1258522]

23. Silencing of Genes and Alleles by RNAi in Anopheles gambiae. Lamacchia M, Clayton JR, Wang-Sattler R, Steinmetz LM, Levashina EA, Blandin SA., 2012 – Methods Mol Biol. 923:161-76 pubmed

22. Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Blandin S.A., Wang-Sattler R., Lamacchia M., Gagneur J., Lycett G., Ning Y., Levashina E.A., Steinmetz L.M., 2009 Oct – Science 326(5949):147-50 pubmed

21. Two Mosquito LRR Proteins Function as Complement Control Factors in the TEP1-Mediated Killing of Plasmodium. Fraiture M., Baxter R.H., Steinert S., Chelliah Y., Frolet C., Quispe-Tintaya W., Hoffmann J.A., Blandin S.A., Levashina E.A., 2009 Mar – Cell Host Microbe. 5(3):273-84 pubmed

20. Antimalarial responses in Anopheles gambiae: from a complement-like protein to a complement-like pathway. Blandin S.A., Marois E., Levashina E.A., 2008 – Cell Host Microbe. 12;3(6):364-74. Review. pubmed

19. Reverse Genetics Analysis of Antiparasitic Responses in the Malaria Vector, Anopheles gambiae. Blandin S.A., Levashina E.A., 2008 – Methods Mol Biol. 415:365-77 pubmed

18. Mosaic Genome Architecture of the Anopheles gambiae Species Complex. Wang-Sattler R., Blandin S., Ning Y., Blass C., Dolo G., Touré Y.T., Torre A.D., Lanzaro G.C., Steinmetz L.M., Kafatos F.C., Zheng L., 2007 – PLoS One 2(11):e1249 pubmed

17. Phagocytosis in mosquito immune responses. Blandin S.A., Levashina E.A., 2007 – Immunol Rev. 219:8-16. pubmed

16. Structural basis for conserved complement factor-like function in the antimalarial protein TEP1. Baxter R.H., Chang C.I., Chelliah Y., Blandin S., Levashina E.A., Deisenhofer J., 2007 – Proc. Natl. Acad. Sci. U.S.A. 104(28):11615-20 pubmed

15. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Waterhouse R.M., Kriventseva E.V., Meister S., Xi Z., Alvarez K.S., Bartholomay L.C., Barillas-Mury C., Bian G., Blandin S., Christensen B.M., Dong Y., Jiang H., Kanost M.R., Koutsos A.C., Levashina E.A., Li J., Ligoxygakis P., Maccallum R.M., Mayhew G.F., Mendes A., Michel K., Osta M.A., Paskewitz S., Shin S.W., Vlachou D., Wang L., Wei W., Zheng L., Zou Z., Severson D.W., Raikhel A.S., Kafatos F.C., Dimopoulos G., Zdobnov E.M., Christophides G.K., 2007 – Science 316(5832):1738-43 pubmed

14. Malaria Plasmodium agent induces alteration in the head proteome of their Anopheles mosquito host. Lefevre T., Thomas F., Schwartz A., Levashina E.A., Blandin S., Brizard J-P., Le Bourligu L., Demettre E., Renaud F., Biron D.G., 2007 – Proteomics 7(11):1908-15 pubmed

13. Boosting NF-kB Dependent Basal Immnity of Anopheles gambiae Aborts Development of Plasmodium berghei. Frolet C., Thoma M., Blandin S., Hoffmann J.A. and Levashina E.A., 2006 – Immunity 25(4):677-85. pubmed

12. In Vivo Identification of Novel Regulators and Conserved Pathways of Phagocytosis in A. gambiae. Moita L.F., Wang R., Michel K., Blandin S., Zimmermann T., Levashina E.A. and Kafatos F.C., 2005 – Immunity 23(1):65-73. pubmed

11. The solubility and stability of recombinant proteins are increased by their fusion to NusA. De Marco V., Stier G., Blandin S., and de Marco A., 2004 Biochem. Biophys. Res. Commun. 322(3):766-771 pubmed

10. Curing mosquitoes to control malaria ? Blandin S. and Levashina, E. A., 2004 – Med. Sci. (Paris) 20(8-9):740-742. pubmed

9. Bacterial alpha2-macroglobulins: colonization factors acquired by horizontal gene transfer from the metazoan genome ? Budd A., Blandin S., Levashina E.A., and Gibson T.J., 2004 – Genome Biology 5(6):R38 pubmed

8. Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae. Blandin S, Shiao S.-H, Moita L.F., Janse C.J., Waters A.P., Kafatos F.C., Levashina E.A., 2004 – Cell 116(5):661-670 pubmed

7. Thioester-containing proteins in insect immunity. Blandin S. and Levashina E.A., 2004 – Mol. Immunol. 40(12):903-908 (Review) pubmed

6. Mosquito immune responses against malaria parasites. Blandin S. and Levashina E.A., 2004 – Curr. Opin. Immunol. 16(1):16-20 (Review). pubmed

5. Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies. Goto A., Blandin S., Royet J., Reichhart J-M., Levashina E.A., 2003 – Nucleic Acids Res. 31(22):6619-6623 pubmed

4. Immunity-related genes and gene families in Anopheles gambiae. Christophides G.K., Zdobnov E., Barillas-Mury C., Birney E., Blandin S., Blass C., Brey P.T., Collins F.H., Danielli A., Dimopoulos G., Hetru C., Hoa N.T., Hoffmann J.A., Kanzok S.M., Letunic I., Levashina E.A., Loukeris T.G., Lycett G., Meister S., Michel K., Moita L.F., Muller H.M., Osta M.A., Paskewitz S.M., Reichhart J.-M., Rzhetsky A., Troxler L., Vernick K.D., Vlachou D., Volz J., von Merig C., Xu J., Zheng L., Bork P., Kafatos F.C. 2002 – Science 298(5591):159-165 pubmed

3. Reverse genetics in the mosquito, Anopheles gambiae: targeted disruption of the Defensin gene. Blandin S., Moita L.F, Kocher T., Wilm M., Kafatos F.C., Levashina E.A., 2002 – EMBO Reports 3(9):852-856 pubmed

2. Thioester-Containing Proteins of Protostomes. Levashina E.A., Blandin S., Moita L.F., Lagueux, M., Kafatos F.C., 2002 – In Infectious Disease: Innate Immunity. Ezekowitz R.A.B. and Hoffmann J.A., eds. Humana Press Inc, Totowa, NJ, 155-173.

1. Conserved Role of a Complement-like Protein in Phagocytosis Revealed by dsRNA Knockout in Cultured Cells of the Mosquito, Anopheles gambiae. Levashina E.A., Moita L.F., Blandin S., Vriend G., Lagueux M., Kafatos F.C., 2001 – Cell 104(5):709-718