A new website for the CNRS UPR9022 unit !

The IBMC (Institute for Molecular and Cellular Biology) comprises three CNRS (National Center for Scientific Research) Units, UPR 9002, UPR 9021 and UPR 9022. Even though they develop distinct research fields, the interest of merging these Units into the same building is an incentive toward the emergence of new research programs utilizing the diverse expertise existing among the scientists. Also, this allows the sharing of materials and techniques as well as rationalizing core facilities.

Insects, as all invertebrates, possess a very powerful defense system against microbial infections by utilizing an immune response of the innate type. Drosophila is the model system of the UPR 9022 (Immune Response and Development in Insects, RIDI) to investigate the evolution of this innate response. In drosophila, the defence mechanisms consist mostly in a humoral response comprising the rapid synthesis and secretion into the blood of a battery of broad spectrum antimicrobial peptides against bacteria and fungi. These are the effectors of the humoral response. At least two distinct control pathways enable induction of the antifungal and antibacterial peptides, respectively.

Four groups study this immune system in drosophila in the UPR 9022, the fifth one (the Anopheles group) being interested in understanding how the Anopheles mosquito can fight against the malaria parasite.